Nuclear organization and 3D chromatin architecture in cognition and neuropsychiatric disorders
نویسندگان
چکیده
منابع مشابه
Chromatin architecture and nuclear RNA.
The maintenance of normal chromatin morphology requires ongoing RNA synthesis. We have examined the role of RNA in chromatin organization, using selective detergent extraction of cells, RNA synthesis inhibitors, and enzymatic digestion of nuclear RNA. Comparison of extracted and unextracted cells showed that the important features of chromatin architecture were largely unchanged by the extracti...
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The fifth U.K. meeting on nuclear envelope disease and chromatin brought together international experts from across the field of nuclear envelope biology to discuss the advancements in a class of tissue-specific degenerative diseases called the laminopathies. Clinically, these range from relatively mild fat-wasting disorders to the severe premature aging condition known as Hutchinson-Gilford pr...
متن کاملSpecial Issue: Cognition in Neuropsychiatric Disorders Computational psychiatry
P. Read Montague, Raymond J. Dolan, Karl J. Friston and Peter Dayan 1 Virginia Tech Carilion Research Institute and Department of Physics, Virginia Tech, 2 Riverside Circle, Roanoke, VA 24016, USA 2 Wellcome Trust Centre for Neuroimaging, University College London, 12 Queen Square, London, WC1N 3BG, UK 3 Gatsby Computational Neuroscience Unit, Alexandra House, 17 Queen Square, London, WC1N 3AR, UK
متن کاملNuclear Architecture and Epigenetics of Lineage Choice
Differentiation is an epigenetic process which is installed by changes of transcriptional programs over successive cellular divisions. A number of studies have reported the effects of biochemical modifications of chromatin (DNA and chromatin proteins) on the regulation of transcription. Although, these studies are able to explain how transcription of a given gene is regulated (toward activation...
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ژورنال
عنوان ژورنال: Molecular Brain
سال: 2016
ISSN: 1756-6606
DOI: 10.1186/s13041-016-0263-x